Yesterday I met with my SIRM RE to discuss my next FET. We decided to try Neupogen, which did not come as a surprise to me, considering we had been discussing it over email. I will be doing 0.4mL every 4 days, starting the first day of progesterone. My WBC will not be monitored, which is a bit concerning to me, but I was assured the dose was small enough that I was not at any risk. I am encouraged by the small studies I have read so far about the high success rate with women who have unexplained RPL, but I know this is not a magic cure. I felt sure PGS would be the answer, and it wasn’t. So I can’t really bring myself to put much stock in any treatments at this point.
I also came away from this meeting pretty concerned about the quality of my remaining frozen embryos. What we transferred for my first FET that wound up a chemical pregnancy was a day 6 blast, and was my only expanded, best quality one. What we have left are 2 average-graded, unexpanded blasts. One is a day 5 which is fine, the other is a day 6. My understanding is an unexpanded blast at day 6 is no bueno.
My SIRM RE says it is definitely worth transferring both over two separate eSET’s because even “ugly” embryos can become babies. But I feel totally hopeless about the remaining day 6. The thought of investing time, money and more Lupron craziness on a cycle with a crappy embryo is really hard to swallow. My mind is made up that I want to transfer both remaining embryos next cycle, but my husband strongly disagrees. He is very wary of the risks associated with twins, and while those are not lost on me, they are risks I am willing to accept.
I have no idea how we are going to come to a decision on this. For now I am taking the healthy, mature approach of avoiding discussing the topic simply because it stresses me out too much to deal with it right now.